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A minitablet formulation made from electrospun nanofibers.

Bettina Poller1, Clare Strachan2, Roland Broadbent3

  • 1School of Pharmacy, University of Otago, Dunedin, New Zealand.

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V
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PubMed
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Electrospun drug-loaded nanofibers offer a novel matrix for minitablets. This formulation enhances drug solubility and dissolution, showing promise for pharmaceutical development.

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Drug Delivery

Background:

  • Poorly water-soluble drugs present formulation challenges.
  • Electrospinning offers a method for creating drug-loaded nanofibers.
  • Minitablets are a suitable dosage form for specific patient populations.

Purpose of the Study:

  • To evaluate electrospun drug-loaded nanofibers as a matrix for minitablets.
  • To assess the physical and chemical properties of prednisone-loaded polyvinylpyrrolidone (PVP) nanofibers.
  • To investigate the stability and dissolution characteristics of the formulated minitablets.

Main Methods:

  • Electrospinning of prednisone into povidone (PVP) nanofibers.
  • Compression of nanofiber mats into minitablets (2mm diameter).
  • Characterization using SEM, DSC, XRPD, and dissolution testing.

Main Results:

  • SEM confirmed a nano-web structure with 400-500nm fiber diameter.
  • Minitablets met US Pharmacopeia standards for content uniformity and friability.
  • DSC and XRPD indicated a stable, one-phase amorphous drug-polymer system with no recrystallization after 10 months.
  • Improved solubility and dissolution properties were observed.

Conclusions:

  • Electrospun nanofibers provide a viable matrix for minitablet development.
  • The amorphous drug-polymer system enhances drug properties.
  • This approach shows potential for improving the delivery of poorly soluble drugs.