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Updated: Feb 16, 2026

Determination of the Optimal Chromosomal Locations for a DNA Element in Escherichia coli Using a Novel Transposon-mediated Approach
Published on: September 11, 2017
Tuning Chromosomal Instability to Optimize Tumor Fitness
Mark E Burkard1,2, Beth A Weaver3,4
1Department of Medicine Hematology/Oncology, University of Wisconsin-Madison, Madison, Wisconsin.
None:
Low rates of chromosomal instability (CIN) are weakly tumor promoting, whereas high rates of CIN cause cell death and tumor suppression. In this context, Sansregret and colleagues show that one mechanism to restrain excessive CIN in tumor cells and increase fitness is through mutations in the anaphase promoting complex/cyclosome. This serves to delay mitotic progression and decrease the rate of chromosome missegregation. Cancer Discov; 7(2); 134-6. ©2017 AACRSee related article by Sansregret et al., p. 218.
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