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Gastritis-II: Pathophysiology

Gastritis-II: Pathophysiology

Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...

Gastritis-I: Introduction and Types

Gastritis-I: Introduction and Types

Gastritis, defined by the inflammation or irritation of the stomach lining or gastric mucosa, manifests in several distinct forms: acute, chronic, reactive, and a specific subtype known as autoimmune metaplastic atrophic gastritis.
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...

Peptic Ulcer Disease I: Introduction

Peptic Ulcer Disease I: Introduction

Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies

Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.

Gastritis III: Clinical Manifestations and Management

Gastritis III: Clinical Manifestations and Management

The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...

Peptic Ulcer Disease V: Surgical Management and Nursing Care

Peptic Ulcer Disease V: Surgical Management and Nursing Care

Surgical management and nursing care are crucial in treating Peptic Ulcer Disease (PUD). Here is an organized and enhanced overview of the surgical interventions and the associated nursing care for PUD:
Surgical Interventions for Peptic Ulcer Disease

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Related Experiment Video

Updated: Mar 7, 2026

Author Spotlight: Generation of and Comparison Between Patient-Derived Gastric Organoids from Different Regions of the Stomach

Author Spotlight: Generation of and Comparison Between Patient-Derived Gastric Organoids from Different Regions of the Stomach

Published on: January 26, 2024

Primary gastric plasmacytoma: a rare entity.

Rui Caetano Oliveira¹, Pedro Amaro², Maria José Julião¹

¹Department of Pathology, Hospitais da Universidade de Coimbra, Coimbra, Portugal.

BMJ Case Reports

|February 8, 2017

Summary

Extramedullary plasmacytomas are rare plasma cell tumors. This case highlights primary gastric plasmacytoma, a potentially misdiagnosed condition, with successful long-term patient outcome.

Related Experiment Videos

Last Updated: Mar 7, 2026

Author Spotlight: Generation of and Comparison Between Patient-Derived Gastric Organoids from Different Regions of the Stomach

Author Spotlight: Generation of and Comparison Between Patient-Derived Gastric Organoids from Different Regions of the Stomach

Published on: January 26, 2024

Area of Science:

Oncology
Pathology

Background:

Extramedullary plasmacytomas (EP) are rare plasma cell neoplasms, typically affecting the head and neck.
Gastric plasmacytoma (GP) is the second most common site for EP, often presenting with non-specific symptoms.
GP can be misdiagnosed as other gastric malignancies like adenocarcinoma, stromal tumors, or lymphomas.

Observation:

A case of primary gastric plasmacytoma presented incidentally as a polypoid lesion.
Histopathological evaluation revealed sheets of mature and immature plasmacytes.
Immunohistochemistry confirmed CD138 positivity, and Helicobacter pylori was not identified.

Findings:

The patient was diagnosed with primary gastric plasmacytoma.
The tumor was characterized by monoclonal plasma cells.
No evidence of Helicobacter pylori infection was found.

Implications:

Accurate pathological diagnosis is crucial for differentiating GP from other gastric tumors.
Early detection and treatment of gastric plasmacytoma can lead to favorable long-term outcomes.
This case underscores the importance of considering rare diagnoses in gastric pathology.