Hypertensive Retinopathy in Takayasu Arteritis
Amadeo R Rodriguez1, Ryan Rebello2, Nader Khalidi3
1Division of Ophthalmology and Division of Neurology.
Neuro-Ophthalmology (Aeolus Press)
|February 8, 2017
Summary
A young woman experienced painless vision loss due to high blood pressure in her eyes. This was linked to Takayasu arteritis and narrowed renal arteries.
Area of Science:
- Ophthalmology
- Cardiology
- Nephrology
Background:
- Takayasu arteritis is a rare inflammatory condition affecting large arteries.
- Renal artery stenosis can lead to severe hypertension.
- Hypertensive retinopathy is a complication of high blood pressure affecting the eyes.
Purpose of the Study:
- To report a case of vision loss secondary to hypertensive retinopathy.
- To highlight the association between Takayasu arteritis, renal artery stenosis, and ocular complications.
- To emphasize the importance of early diagnosis and management of these interconnected conditions.
Main Methods:
- Case report presentation.
- Review of patient's medical history, clinical findings, and diagnostic workup.
- Ophthalmological examination including fundoscopy.
- Imaging studies to assess Takayasu arteritis and renal artery stenosis.
Main Results:
- The patient presented with painless vision loss.
- Fundoscopy revealed signs consistent with hypertensive retinopathy.
- Diagnosis of Takayasu arteritis and renal artery stenosis was confirmed.
- Hypertension was identified as the underlying cause of retinopathy.
Conclusions:
- Hypertensive retinopathy can be an early sign of systemic vasculitis like Takayasu arteritis.
- Renal artery stenosis in conjunction with Takayasu arteritis poses a significant risk for severe hypertension and subsequent vision loss.
- Multidisciplinary management is crucial for patients with Takayasu arteritis and renal artery stenosis to prevent irreversible complications.
Related Concept Videos
Hypertension II: Pathophysiology
1.3K
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
1.3K
Hypertension III: Clinical Manifestations and Diagnostic Studies
690
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
690
Glaucoma: Overview
1.6K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.6K
Antihypertensive Drugs: Direct Renin Inhibitors
1.7K
The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
1.7K
Antihypertensive Drugs: Angiotensin II Receptor Blockers
2.9K
In the renin-angiotensin-aldosterone system, a hormone called angiotensin II plays a crucial role. It binds to the AT1 receptors in vascular smooth muscles coupled with Gq proteins. The activation of these receptors activates an enzyme called phospholipase C, which releases two molecules: inositol trisphosphate and diacylglycerol. These molecules cause a chain reaction that leads to the phosphorylation of myosin light chains and promotes interaction between actin and myosin, leading to smooth...
2.9K
Open Angle Glaucoma: Treatment
1.1K
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.1K


