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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Related Experiment Video

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Optic Atrophy in End-Stage Giant Axonal Neuropathy: A Case Report.

T J Wubben1, A O Eghrari2, A N McCoy3

  • 1Biochemistry and Molecular Genetics, University of Illinois at Chicago Chicago, Illinois USA.

Neuro-Ophthalmology (Aeolus Press)
|February 8, 2017
PubMed
Summary
This summary is machine-generated.

Giant axonal neuropathy (GAN) can cause optic nerve damage, leading to vision loss. Optical coherence tomography (OCT) may help monitor this rare neurological condition.

Keywords:
Giant axonal neuropathyOCTnon-glaucomatous cuppingoptic atrophyretinal nerve fibre layer

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Area of Science:

  • Neuro-ophthalmology
  • Neurology
  • Genetics

Background:

  • Giant axonal neuropathy (GAN) is a rare, inherited neurodegenerative disorder.
  • Ocular manifestations of GAN are not well-documented.
  • This case highlights potential visual pathway involvement in GAN.

Observation:

  • A 32-year-old woman with biopsy-proven GAN presented with vision impairment.
  • Fundus examination revealed bilateral optic atrophy (cup-to-disc ratio 0.7).
  • Kinetic visual fields showed moderate bilateral constriction.

Findings:

  • Optical coherence tomography (OCT) demonstrated diffuse retinal nerve fiber layer (RNFL) thinning.
  • This RNFL thinning pattern is atypical for common optic neuropathies.
  • The observed changes are likely secondary to GAN-associated optic atrophy.

Implications:

  • OCT may serve as a non-invasive tool for monitoring disease progression in GAN.
  • This approach could be valuable for future therapeutic trials in GAN.
  • Early detection of ocular involvement in GAN is crucial for patient management.