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Accommodation Paralysis after Pheniramine Maleate Injection: A Case Report
Pinar Bingol Kiziltunc1, Huban Atilla1, F Nilufer Yalcindag1
1Department of Ophthalmology, Faculty of Medicine, Ankara University Dikimevi, Ankara Turkey.
Neuro-Ophthalmology (Aeolus Press)
|February 8, 2017
Summary
Gilbert syndrome, a genetic condition, can lead to drug metabolism issues. This case highlights its link to neuro-ophthalmic complaints like temporary vision loss due to medication side effects.
Area of Science:
- Ophthalmology
- Genetics
- Pharmacology
Background:
- Drug-induced vision problems can stem from various health issues.
- Accommodative insufficiency, or loss of focusing ability, has multiple potential causes.
Observation:
- A 29-year-old man experienced acute accommodation paralysis and blurred vision after a pheniramine maleate injection.
- His symptoms emerged immediately post-injection and resolved within 10 days.
Findings:
- Systemic evaluation and lab tests led to a Gilbert syndrome diagnosis.
- Pheniramine maleate metabolism is potentially impaired in Gilbert syndrome, causing anticholinergic effects and accommodation paralysis.
Implications:
- This case underscores the importance of considering Gilbert syndrome in patients with unexplained neuro-ophthalmic symptoms after drug administration.
- Understanding drug metabolism in genetic conditions like Gilbert syndrome is crucial for safe and effective treatment.
- Highlights the link between genetic metabolic disorders and ocular side effects of medications.
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