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Published on: June 10, 2025
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Exploring the relation between changes in NT-proBNP and renal function in patients with suspected heart failure using
Jufen Zhang1, Kenneth Y-K Wong2, Andrew L Clark2
1Department of Academic Cardiology, Castle Hill Hospital, Hull, UK; Faculty of Medical Science, Anglia Ruskin Universality, UK.
International Journal of Cardiology
|February 8, 2017
Summary
Changes in N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels over one year were primarily determined by baseline NT-proBNP. Renal function (eGFR) did not directly influence these changes in patients with suspected heart failure.
Area of Science:
- Cardiology
- Nephrology
- Biomarker Research
Background:
- Traditional regression models may oversimplify the relationship between NT-proBNP and renal function.
- Understanding factors influencing NT-proBNP changes is crucial for heart failure management.
Purpose of the Study:
- To investigate the determinants of NT-proBNP change over one year in patients with suspected heart failure.
- To explore the association between NT-proBNP changes and renal function, specifically estimated glomerular filtration rate (eGFR).
Main Methods:
- Structural Equation Modelling (SEM) was employed to analyze data from 1006 patients.
- Variables assessed included baseline and 1-year NT-proBNP, age, sex, BMI, eGFR, loop diuretics, and ACE inhibitors.
Main Results:
- Baseline NT-proBNP was the strongest predictor of NT-proBNP change at one year (r=0.73, p<0.001).
- Changes in eGFR were not directly associated with changes in NT-proBNP.
- NT-proBNP changes were indirectly associated with age, BMI, eGFR, and loop diuretics (p<0.01).
Conclusions:
- Baseline NT-proBNP level is the principal factor influencing its change over one year.
- Renal function (eGFR) does not appear to be a direct determinant of NT-proBNP fluctuations in this cohort.
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