The Economics of Malaria Vaccine Development
Magdalena Plebanski1, Katie L Flanagan2
1Vaccine and Infectious Diseases Unit, Department of Immunology and Pathology, Monash University, Melbourne, Victoria, Australia; Division of Therapeutics, Monash Institute of Medical Engineering (MIME), Monash University, Melbourne, Victoria, Australia.
Trends in Parasitology
|February 8, 2017
Abstract:
Vaccines that do not take a comprehensive endpoint view of the pathogen population they want to tackle early in their developmental process, may find it financially prohibitive to redesign them once they have progressed down a costly regulatory and human trial pathway. Specifically, the lead malaria vaccine candidate RTS,S has limited ability to tackle parasite polymorphism and may induce sex-specific nonspecific effects (NSEs).
