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Allergic reaction with immune hemolytic anemia resulting from chlorambucil
L Thompson-Moya1, T Martin, H G Heuft
1Klinikum Charlottenburg der Freien Universität, Berlin, Federal Republic of Germany.
American Journal of Hematology
|November 1, 1989
Abstract:
In a 73-year-old female with chronic lymphocytic leukemia we observed an acute illness with shivering, high fever, and hemolytic anemia following chlorambucil administration. Reexposure in a controlled clinical situation suggested an allergic drug reaction. In an in vitro assay, we were able to demonstrate chlorambucil as the causative agent of immune hemolysis.