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Patch Clamp

Patch Clamp

Many fundamental cell functions such as muscle contraction and nerve transmission rely on the electrical signals produced by the movement of positively and negatively charged ions across the cell membrane. One competent method to record current flowing across the whole cell or single ion channel is the patch-clamp technique.
In this method, a glass micropipette containing electrolyte solution is tightly sealed against a small portion of the cell membrane. As a result, a patch of the cell...

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Related Experiment Video

Updated: Mar 7, 2026

Electrophysiological Analysis of human Pluripotent Stem Cell-derived Cardiomyocytes hPSC-CMs Using Multi-electrode Arrays MEAs

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Open Ephys: an open-source, plugin-based platform for multichannel electrophysiology.

Joshua H Siegle¹, Aarón Cuevas López, Yogi A Patel

¹Allen Institute for Brain Science, 615 Westlake Ave N, Seattle, WA 98109, United States of America, jsiegle on GitHub.

Journal of Neural Engineering

|February 8, 2017

Summary

This summary is machine-generated.

Researchers developed open-source software to simplify closed-loop neuroscience experiments. The Open Ephys GUI enables easier development and sharing of real-time feedback algorithms for greater experimental reproducibility.

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A Computer-assisted Multi-electrode Patch-clamp System

A Computer-assisted Multi-electrode Patch-clamp System

Published on: October 18, 2013

Area of Science:

Neuroscience
Computational Neuroscience
Biotechnology

Background:

Closed-loop experiments are crucial for understanding neural systems but are technically challenging to implement and replicate.
The need for precise, reproducible experimental setups limits the widespread adoption of advanced neuroscience techniques.

Purpose of the Study:

To develop an open-source software solution that simplifies the creation and sharing of algorithms for closed-loop neuroscience experiments.
To lower the barrier to entry for electrophysiologists seeking to integrate real-time feedback into their research.

Main Methods:

Developed the Open Ephys GUI, an open-source platform for multichannel electrophysiology.
Integrated modules for real-time feedback delivery based on detected neural events.
Implemented a plugin-based architecture allowing users to extend functionality via a simple API.

Main Results:

The Open Ephys GUI facilitates the development and sharing of custom algorithms for closed-loop control.
Successfully used the software with open-source hardware for phase-specific perturbation of hippocampal theta rhythm.
The platform supports multichannel electrophysiology with a novel plugin-based workflow.

Conclusions:

The Open Ephys GUI significantly enhances the accessibility and reproducibility of closed-loop neuroscience experiments.
This open-source tool empowers researchers to incorporate sophisticated real-time feedback mechanisms into their studies.
The plugin architecture fosters collaboration and innovation within the neuroscience research community.