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Advances in lactoferrin research concerning bovine mastitis
Kei-Ichi Shimazaki1, Kazuhiro Kawai2
1a Fuji Woman's University, Sapporo, 001-0016, Japan.
Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
|February 8, 2017
Summary
Lactoferrin, an iron-binding glycoprotein in milk, is crucial for mammal development and preventing mammary gland infections. Research shows its concentration changes in bovine mastitis milk and its role in immune defense and treatment.
Area of Science:
- Veterinary Immunology
- Biochemistry
- Dairy Science
Background:
- Lactoferrin is an iron-binding glycoprotein in milk and secretions.
- It is vital for newborn development and innate immunity against mammary gland infections.
- Mastitis is udder inflammation caused by bacterial infection.
Purpose of the Study:
- To review research on lactoferrin's role in bovine mastitis.
- To explore lactoferrin concentration changes, antimicrobial activity, immune function, and therapeutic applications in mastitis.
Main Methods:
- Literature review of studies on lactoferrin and bovine mastitis.
- Analysis of research trends from the 1970s to the present.
- Synthesis of findings on lactoferrin's concentration, activity, and immune involvement.
Main Results:
- Lactoferrin concentration in milk fluctuates during bovine mastitis.
- Lactoferrin exhibits antimicrobial activity against mastitis pathogens.
- Studies have elucidated lactoferrin's immune system participation and its use in mastitis prevention and treatment.
Conclusions:
- Lactoferrin plays a significant role in bovine mammary gland health and immunity.
- Research has evolved from observing concentration changes to understanding mechanisms and therapeutic potential.
- Lactoferrin is a promising agent for mastitis management in dairy cows.
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