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Combined Phosphoramidite-Phosphodiester Reagents for the Synthesis of Methylene Bisphosphonates

Sander B Engelsma1, Nico J Meeuwenoord1, Hermen S Overkleeft1

  • 1Leiden Institute of Chemistry, Department of Bioorganic Synthesis, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands.

Angewandte Chemie (International Ed. in English)
|February 8, 2017
PubMed

Keywords:
methylene bisphosphonatesphosphanylmethylphosphonatephosphorylationpyrophosphate bioisosteressolid-phase synthesis

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