Natural Product Synthesis via Palladium-Catalyzed Carbonylation
Yu Bai1, Dexter C Davis1, Mingji Dai1
1Department of Chemistry and Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States.
Abstract:
Carbon monoxide is an important one-carbon source and can be incorporated in complex molecules via various transition-metal-catalyzed carbonylation reactions. In particular, palladium-catalyzed carbonylation reactions have found broad application in total synthesis of natural products. Examples are presented in this Synopsis to highlight recent progress in this area, including our own work in macrolide and spirocyclic molecule synthesis. In these selected cases, carbon monoxide functions as a one-carbon linchpin to facilitate building structural complexity and improving synthetic efficiency.
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