Related Experiment Video
Updated: Mar 7, 2026

An Ex vivo Model to Study Hormone Action in the Human Breast
Published on: January 8, 2015
Progesterone-Containing Gel Does Not Eliminate Postpartum Breast Engorgement?
1Department of Physiology, Faculty of Biology, St. Petersburg State University , St. Petersburg, Russia .
Topical progesterone gel (Progestogel) did not alleviate severe postpartum breast engorgement in lactating women. The study found no reduction in breast swelling or tenderness within 20 minutes of application.
Area of Science:
- Obstetrics and Gynecology
- Lactation and Breastfeeding
- Dermatology
Background:
- Severe postpartum breast engorgement causes significant maternal discomfort.
- Engorgement can impede infant breastfeeding success.
- Investigating novel treatments for postpartum breast engorgement is crucial.
Purpose of the Study:
- To evaluate the efficacy of percutaneous progesterone-containing gel (Progestogel) in resolving severe postpartum breast engorgement.
- To determine if transdermal Progestogel application can reduce breast swelling, engorgement, and tenderness.
Main Methods:
- A study involving 23 lactating women experiencing severe postpartum breast engorgement.
- Transdermal application of 2.5-3g of Progestogel to the breast.
- Measurement of mammary gland density using a tonometer before and 20 minutes after gel application.
Main Results:
- Application of Progestogel did not lead to a reduction in breast swelling.
- No significant decrease in breast engorgement or tenderness was observed within 20 minutes.
- Tonometer readings indicated no change in mammary gland density post-application.
Conclusions:
- Transdermal application of Progestogel is ineffective in reducing postpartum breast engorgement.
- The study did not support the use of Progestogel for managing severe breast engorgement in lactating women.
- Further research may be needed to explore alternative treatments for this condition.
Related Concept Videos
The Mammary Glands
Each breast features a pigmented projection known as the nipple, through which milk emerges via closely spaced openings of ducts, referred to as lactiferous ducts. Surrounding the nipple is a circular pigmented area of skin named the areola, which appears rough due to...
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
Proliferative Phase
Notably, the stratum basale, the basal layer of the endometrium, including the basal parts of the uterine glands, remains unaffected by menstruation. Stem cells in this layer undergo mitosis, regenerating the stratum functionalis and thickening the...
Gonadal and Placental Hormones
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
GPCRs Regulate Adenylyl Cylase Activity
Drugs for Peptic Ulcer Disease: Prostaglandin Analogs as Mucosal Protective Agents
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...

