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Related Concept Videos

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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  6. Exhausting Alloreactivity Of Donor-derived Car T Cells
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  6. Exhausting Alloreactivity Of Donor-derived Car T Cells

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Exhausting alloreactivity of donor-derived CAR T cells

Maksim Mamonkin1, Helen E Heslop1

  • 1Center for Cell and Gene Therapy, Baylor College of Medicine, Houston Methodist Hospital and Texas Children's Hospital, Houston, Texas, USA.

Nature Medicine
|February 8, 2017
Summary

No abstract available in PubMed .

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