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Related Experiment Videos

Dementia with coexistent major depression.

B S Greenwald1, E Kramer-Ginsberg, D B Marin

  • 1Department of Psychiatry, Mount Sinai School of Medicine, New York, N.Y.

The American Journal of Psychiatry
|November 1, 1989
PubMed
Summary
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Major depression frequently co-occurs with dementia. Antidepressant therapy effectively improved depressive symptoms in dementia patients, though cognitive function remained impaired.

Area of Science:

  • Geropsychiatry
  • Neurology
  • Psychiatry

Background:

  • Major depression is a common comorbidity in dementia patients.
  • Dementia patients often present with depressive symptoms that can complicate diagnosis and treatment.

Purpose of the Study:

  • To investigate the prevalence of major depression in dementia patients.
  • To compare the treatment response and clinical presentation of depression in patients with and without dementia.

Main Methods:

  • Prospective comparison of 10 dementia/depression patients with 10 non-depressed demented patients and 33 non-demented depressed patients.
  • Assessment of depression, cognition, and memory using pretreatment and posttreatment ratings.

Main Results:

Related Experiment Videos

  • Eleven percent of dementia patients met criteria for major depression.
  • Seventy percent of dementia/depression patients responded to antidepressant therapy, similar to the depression-only group.
  • Depression in dementia patients lowered cognitive test performance, which improved after treatment, though cognitive impairment persisted.

    • Conclusions:

    • Major depression is a significant issue in dementia care.
    • Antidepressant treatment is effective for depressive symptoms in dementia patients.
    • While treatment improves cognitive test performance, underlying cognitive impairment in dementia persists.