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Polymer Classification: Stereospecificity

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Polymerization generates chiral centers along the entire backbone of a polymer chain. Accordingly, the stereochemistry of the substituent group has a significant effect on polymer properties. Polymers formed from monosubstituted alkene monomers feature chiral carbons at every alternate position in the polymer backbone. Relative to the predominant orientation of substituents at the adjacent chiral carbons, the polymer can exist in three different configurations: isotactic, syndiotactic, and...

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Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications

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Immiscible poly(lactic acid)/poly(ε-caprolactone) for temporary implants: Compatibility and cytotoxicity.

Pablo F M Finotti¹, Lidiane C Costa², Ticiana S O Capote³

¹Department of Materials Engineering, Engineering School of São Carlos, University of São Paulo - USP, São Carlos, São Paulo 13563-120, Brazil.

Journal of the Mechanical Behavior of Biomedical Materials

|February 8, 2017

Summary

A novel triblock copolymer enhances poly(lactic acid)/poly(ε-caprolactone) blend compatibility and toughness. This bioresorbable material shows no cytotoxicity, making it promising for biomedical applications.

Keywords:

Compatibility Cytotoxicity Mechanical properties Morphology PLA/PCL blends

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Area of Science:

Materials Science
Polymer Science
Biomaterials Engineering

Background:

Immiscible polymer blends like poly(lactic acid) (PLA) and poly(ε-caprolactone) (PCL) often suffer from poor compatibility and mechanical properties.
Improving the interfacial adhesion and overall performance of PLA/PCL blends is crucial for their application in biomedical fields.

Purpose of the Study:

To investigate the effect of a low molecular weight triblock copolymer (CT) on the compatibility and cytotoxicity of PLA/PCL blends.
To enhance the mechanical properties, particularly ductility and toughness, of these bioresorbable polymer blends.

Main Methods:

PLA/PCL blends were prepared using melt mixing in a twin-screw extruder.
Morphological, mechanical, and thermal properties were analyzed using SEM, tensile/Izod impact tests, DMA, and DSC.
Cytotoxicity was assessed using the XTT assay.

Main Results:

The CT copolymer effectively suppressed domain coalescence, maintaining dispersed PCL domains at ~0.35µm.
PLA/PCL blends with 5wt% CT copolymer showed significant improvements in ductility and toughness.
DMA indicated the CT copolymer plasticized the PCL phase, enhancing interfacial adhesion.

Conclusions:

The CT triblock copolymer acts as an effective compatibilizer for PLA/PCL blends, improving their morphology and mechanical performance.
Compatibilized PLA/PCL blends demonstrate no adverse cytotoxic effects, indicating their suitability for biomedical applications.