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Updated: Mar 7, 2026

T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing
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ARResT/Interrogate: an interactive immunoprofiler for IG/TR NGS data.

Vojtech Bystry1, Tomas Reigl1, Adam Krejci1,2

  • 1CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic.

Bioinformatics (Oxford, England)
|February 8, 2017
PubMed
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This summary is machine-generated.

Analyzing immune repertoire data from next-generation sequencing is complex. ARResT/Interrogate is a new web tool that simplifies organizing and visualizing immunogenetic data for researchers.

Area of Science:

  • Immunology
  • Bioinformatics
  • Computational Biology

Background:

  • Next-generation sequencing (NGS) enables deep exploration of immune repertoires, including immunoglobulins and T cell receptors.
  • The vast variability and complexity of immune responses present significant analytical challenges.

Purpose of the Study:

  • To develop a user-friendly application for organizing, filtering, and analyzing large-scale immunogenetic datasets.
  • To facilitate the interpretation of complex immune repertoire data through interactive visualizations.

Main Methods:

  • Implementation of ARResT/Interrogate, a web-based interactive application.
  • Utilizing R programming language for primary development.
  • Integration of numerous filtering criteria and statistical calculations.

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Main Results:

  • ARResT/Interrogate effectively organizes and filters large immunogenetic datasets.
  • The application provides multiple interconnected visualizations for data interpretation.
  • It calculates relevant statistics for immune repertoire analysis.

Conclusions:

  • ARResT/Interrogate offers a streamlined approach to analyzing complex immune repertoire data.
  • The tool enhances the exploration of immune variability and responses.
  • It is freely available online for the research community.