Related Experiment Video
Updated: Mar 7, 2026
Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
Published on: December 1, 2020
CIIPro: a new read-across portal to fill data gaps using public large-scale chemical and biological data
Daniel P Russo1, Marlene T Kim1,2, Wenyi Wang1
1The Rutgers Center for Computational and Integrative Biology, Camden, NJ, USA.
Summary:
We have developed a public Chemical In vitro–In vivo Profiling (CIIPro) portal, which can automatically extract in vitro biological data from public resources (i.e. PubChem) for user-supplied compounds. For compounds with in vivo target activity data (e.g. animal toxicity testing results), the integrated cheminformatics algorithm will optimize the extracted biological data using in vitro–in vivo correlations. The resulting in vitro biological data for target compounds can be used for read-across risk assessment of target compounds. Additionally, the CIIPro portal can identify the most similar compounds based on their optimized bioprofiles. The CIIPro portal provides new powerful assessment capabilities to the scientific community and can be easily integrated with other cheminformatics tools.
Availability And Implementation:
ciipro.rutgers.edu.
Contact:
danrusso@scarletmail.rutgers.edu or hao.zhu99@rutgers.edu
