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Hypomagnesemia and bronchial hyperreactivity. A case report.

G Rolla¹, C Bucca

¹Clinica Medica I, University of Torino, Italy.

|September 1, 1989

Summary

Low magnesium levels were linked to bronchial hyperreactivity in a patient. Magnesium repletion improved airway function, suggesting serum magnesium checks for airway obstruction patients.

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Area of Science:

Pulmonary Medicine
Clinical Biochemistry

Background:

Bronchial hyperreactivity is a key feature of obstructive airway diseases.
Hypomagnesemia, or low serum magnesium, can affect smooth muscle function.

Observation:

A 37-year-old woman, a heavy smoker and alcoholic, presented with bronchial hyperreactivity (PC20 FEV1 0.8 mg/ml).
Her serum magnesium level was critically low at 0.55 mmol/l.

Findings:

Intravenous magnesium sulfate administration (6 g over 24 h) increased serum magnesium to 1.05 mmol/l.
Following magnesium repletion, bronchial hyperreactivity significantly improved, with the histamine PC20 FEV1 increasing to 9.8 mg/ml.

Implications:

This case highlights a potential link between hypomagnesemia and bronchial hyperreactivity.
Checking serum magnesium levels may be important for managing patients with airway obstruction.
Magnesium's role in modulating airway smooth muscle contractility warrants further investigation.

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