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Polymorphism and protein expression of MUTYH gene for risk of rheumatoid arthritis

Shih-Yin Chen1,2, Hsin-Han Chen3, Yu-Chuen Huang1,2

  • 1School of Chinese Medicine, China Medical University, Taichung, 404, Taiwan.

BMC Musculoskeletal Disorders
|February 9, 2017
PubMed
Abstract

Insights

Rheumatoid arthritis (RA) is linked to the MUTYH rs3219463 SNP and higher MUTYH protein levels. This suggests MUTYH may be a potential therapeutic target for RA patients.

Area of Science:

  • Genetics and Immunology
  • Molecular Biology

Background:

  • Rheumatoid arthritis (RA) prevalence is associated with mutY Homolog (E. coli) (MUTYH) SNPs.
  • Previous studies identified associations between RA and specific MUTYH SNPs (rs3219463, rs3219476) in Taiwan.
  • This study investigates if these SNPs influence EGFR expression in RA progression.

Purpose of the Study:

  • To determine the association between MUTYH SNPs and rheumatoid arthritis (RA).
  • To investigate the impact of MUTYH SNPs on RA progression and EGFR expression.
  • To explore MUTYH as a potential therapeutic target for RA.

Main Methods:

  • A cohort study involving 368 Taiwanese Han Chinese RA patients and 364 healthy controls.
  • Analysis of serum MUTYH levels and genomic DNA for the rs3219463 SNP of MUTYH.
  • Statistical analysis to compare genotype frequencies and clinical parameters between RA patients and controls.

Main Results:

  • A significant difference in genotype frequency distribution at rs3219463 was observed between RA patients and controls (p < 0.0002).
  • RA patients carrying the G allele at rs3219463 showed reduced joint pain and lower DAS28 scores (p < 0.006 and p < 0.003, respectively).
  • Elevated serum MUTYH levels were found in RA patients compared to controls (p < 0.005).

Conclusions:

  • Rheumatoid arthritis is associated with the rs3219463 SNP in the EGFR gene and increased serum MUTYH protein levels.
  • These findings highlight the potential role of MUTYH in RA pathogenesis.
  • MUTYH warrants further investigation as a therapeutic target for rheumatoid arthritis.
Keywords:
CNVsMUTYHOxidative DNA damage. DAS28RASNPs

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