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A Sensitive Visual Method for the Detection of Hydrogen Sulfide Producing Bacteria

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Hydrogen sulfide in stroke: Protective or deleterious?

Su Jing Chan¹, Peter T-H Wong²

¹Institute of Medical Biology, Agency for Science, Technology and Research (A*STAR), Singapore; Departments of Radiology and Neurology, Massachusetts General Hospital, Harvard Medical School, USA.

Neurochemistry International

|February 9, 2017

Summary

Hydrogen sulfide (H₂S) acts as a signaling molecule in the central nervous system. Its role in stroke is concentration-dependent, potentially offering protection at low levels and causing harm at high levels.

Keywords:

Hydrogen sulphide Neuroprotection Stroke Toxic effect

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Area of Science:

Neuroscience
Biochemistry
Pathology

Background:

Hydrogen sulfide (H₂S) is recognized as a signaling molecule in the central nervous system.
H₂S levels increase rapidly in the brain following ischemic insults, such as in experimental stroke models.

Purpose of the Study:

To review and synthesize current literature on the role of hydrogen sulfide in ischemic stroke.
To determine whether H₂S is protective or deleterious in the context of stroke.

Main Methods:

Literature review of studies investigating hydrogen sulfide in experimental stroke.
Analysis of evidence regarding the effects of H₂S concentration on ischemic brain injury.

Main Results:

Current evidence does not provide a definitive answer regarding the role of H₂S in stroke.
The effect of H₂S appears to be concentration-dependent: high concentrations may be deleterious, while low concentrations may be protective.

Conclusions:

The dual role of H₂S in ischemic stroke suggests a complex involvement.
Modulating H₂S concentration (either increasing or decreasing it) may represent a potential therapeutic strategy for stroke treatment.