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The expression of lnc-IL-7R long non-coding RNA dramatically correlated with soluble and membrane-bound isoforms of
Parinaz Bina1, Majid Pahlevan Kakhki1, Mohammad Ali Sahraian2
1Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
Background And Purpose:
Multiple sclerosis (MS) is a neurological disease of the central nervous system (CNS) that causes physical and cognitive impairments. IL-7Ra is a key non-MHC gene associated with MS. IL-7Ra is a likely functional candidate for this complex disease because it is involved in the development, maturation, and homeostasis of T and B cells. Our aim was to evaluate the expression level and controlling role of lnc-IL-7R in the expression of two variants of IL-7Ra in MS patients versus healthy controls and their correlation with certain clinical features.
Methods:
Using the real-time PCR method, we analyzed the expression levels of membrane-bound (IL-7RB) and soluble (IL-7RS) isoforms of IL-7R gene and lnc-IL-7R in 36 MS patients versus 30 healthy controls.
Results:
Our results revealed no significant difference between the expression levels of IL-7RB and IL-7RS isoforms of IL-7R gene and lnc-IL-7R in MS patients versus healthy controls (p=0.7, p=0.6 and p=0.8, respectively). Moreover, we found a significant correlation between the expression levels of IL-7RB with lnc-IL-7R, IL-7RS with lnc-IL-7R and IL-7RB with IL-7RS in both patient and control groups.
Conclusions:
We have probably uncovered new evidence for the controlling role of long non-coding RNAs in the expression level of genes and their roles in MS.
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