Recent advances in hepatocellular carcinoma therapy
1Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE 68198, United States.
Pharmacology & Therapeutics
|February 9, 2017
Summary
Hepatocellular carcinoma (HCC) is a deadly cancer with increasing incidence. Nanodelivery systems show promise for targeted treatment of HCC, offering new therapeutic strategies beyond current options.
Area of Science:
- Oncology
- Nanomedicine
- Biotechnology
Background:
- Hepatocellular carcinoma (HCC), or malignant hepatoma, is a lethal cancer characterized by complexity, recurrence, metastasis, and heterogeneity.
- HCC incidence and mortality are rising, particularly in Western countries, linked to the obesity epidemic.
- Risk factors include alcohol consumption, viral hepatitis B and C, metabolic disorders, and age.
Purpose of the Study:
- To review the pathogenesis of Hepatocellular carcinoma (HCC).
- To discuss recent nanodelivery treatment methodologies for HCC.
- To present a synopsis of clinical trials involving monoclonal antibodies (mAbs) and peptide drugs for HCC.
Main Methods:
- Review of the pathogenesis of Hepatocellular carcinoma (HCC).
- Discussion of nanodelivery systems (polymeric nanoparticles, liposomes, micelles) for targeted drug delivery.
- Analysis of recent clinical trials for monoclonal antibodies (mAbs) and peptide drugs in HCC treatment.
Main Results:
- Nanodelivery systems offer potential for targeted treatment of HCC using various therapeutic agents.
- Monoclonal antibodies (mAbs) and peptide drugs delivered via nanoparticles show promise in clinical trials.
- Current treatment options for HCC are limited, with Sorafenib being the only FDA-approved drug.
Conclusions:
- Nanodelivery of therapeutic agents represents a promising frontier for Hepatocellular carcinoma (HCC) treatment.
- Further research and clinical trials are essential to optimize nanomedicine-based therapies for HCC.
- Targeted nanodelivery strategies hold potential to improve efficacy and overcome limitations of existing HCC treatments.
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