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Dual effect of WISP-1 in diverse pathological processes

Mengmeng Feng1, Shuqin Jia2

  • 1Laboratory of Surgery, the Affiliated Hospital, Inner Mongolia Medical University, Hohhot 010050, China.

Chinese Journal of Cancer Research = Chung-Kuo Yen Cheng Yen Chiu
|February 9, 2017
PubMed

Insights

Wnt-1 inducible signaling pathway-1 (WISP-1) is a CCN family protein involved in cell functions and diseases. Its role in cancer varies, acting as an oncogene in some and a tumor suppressor in others.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • Wnt-1 inducible signaling pathway-1 (WISP-1), also known as CCN-4, is a member of the connective tissue growth factor (CTGF) family.
  • WISP-1 is expressed in embryonic stem cells and plays roles in adult organ development, cell proliferation, differentiation, apoptosis, and adhesion.
  • It is implicated in various pathophysiological processes, including embryonic development, inflammation, injury repair, and cancer.

Purpose of the Study:

  • To review the structure, expression, functions, clinical significance, and mechanisms of WISP-1.
  • To explore WISP-1's dual role in cancer progression and non-neoplastic diseases.

Main Methods:

  • Literature review of studies on WISP-1.
  • Analysis of WISP-1's involvement in cellular processes and disease pathology.

Main Results:

  • WISP-1 is highly correlated with tumor progression and malignant transformation.
  • It acts as an oncogene in colorectal cancer, cholangiocarcinoma, hepatocellular carcinoma, and breast cancer.
  • Conversely, WISP-1 exhibits a tumor-suppressing role in lung and prostate cancers.
  • WISP-1 influences cell proliferation, adhesion, motility, invasion, metastasis, and epithelial-to-mesenchymal transition.

Conclusions:

  • WISP-1 has diverse functions and a context-dependent role in cancer.
  • Understanding WISP-1's mechanisms is crucial for developing therapeutic strategies.
Keywords:
WISP-1cancerclinical significancemetastasisoncogenetumor suppressor

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