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Interpleural anesthetics in the dog: differential somatic neural blockade
F X Riegler1, T R VadeBoncouer, D A Pelligrino
1Department of Anesthesiology, Michael Reese Hospital and Medical Center, Chicago, Illinois 60616.
Anesthesiology
|November 1, 1989
Summary
Interpleural bupivacaine causes localized intercostal nerve blockade in dogs, affecting evoked potentials over ribs. Gravity influences spread, with no evidence of spinal, epidural, or central nervous system effects.
Area of Science:
- Anesthesiology
- Neuroscience
- Veterinary Medicine
Background:
- Interpleural bupivacaine is used for analgesia.
- Understanding its neural spread is crucial for safety and efficacy.
Purpose of the Study:
- To investigate the differential somatic neural effects of interpleural bupivacaine in dogs.
- To determine if interpleural bupivacaine causes spinal, epidural, or central nervous system effects.
Main Methods:
- Evoked responses were measured in dogs using electrodes on ribs, thoracic vertebrae (T5L, T7L, T9L), and the sensorimotor cortex (SMC).
- Interpleural bupivacaine (0.5%) was administered via catheters.
- Neural blockade was assessed by changes in amplitude and latency of evoked potentials.
Main Results:
- Interpleural bupivacaine produced intercostal nerve blockade, evidenced by decreased amplitude and increased latency of evoked potentials between T7L and rib electrodes.
- The spread of the blockade was influenced by gravity, localizing to dependent rib areas.
- No significant changes in potentials were observed between T9L-T5L and T9L-SMC electrodes, indicating no spinal, epidural, or CNS effects.
Conclusions:
- Interpleural bupivacaine induces a localized intercostal nerve block.
- Gravity significantly influences the distribution of interpleural bupivacaine.
- This study found no evidence of systemic or central nervous system toxicity from interpleural bupivacaine administration.