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Skin Microbiome in Small- and Large-plaque Parapsoriasis
Alexander Salava1, Pedro Pereira, Velma Aho
1Department of Dermatology and Allergology, University of Helsinki, and Helinki University Hospital, FIN-00250 Helsinki, Finland. alexander.salava@hus.fi.
Acta Dermato-Venereologica
|February 9, 2017
Summary
This study found no significant changes in the skin microbiome of parapsoriasis lesions compared to healthy skin. The cutaneous bacterial microbiome appears unaltered in parapsoriasis patients.
Area of Science:
- Dermatology
- Microbiology
- Immunology
Background:
- Staphylococcal enterotoxins are linked to immune dysregulation in lymphoma.
- Understanding the skin microbiome's role in dermatological conditions is crucial.
Purpose of the Study:
- To investigate alterations in the cutaneous bacterial microbiome of parapsoriasis lesions.
- To compare the skin microbiome of parapsoriasis with contralateral healthy skin.
Main Methods:
- Skin swab samples collected from 13 parapsoriasis patients and healthy controls.
- 16S ribosomal RNA gene sequencing (V1-V3 region) using Illumina MiSeq.
- Analysis of bacterial genera, focusing on Propionibacterium, Corynebacterium, and Staphylococcus.
Main Results:
- Propionibacterium, Corynebacterium, and Staphylococcus were the most common genera.
- Staphylococcus epidermidis was the predominant Staphylococcus species.
- No significant differences were found between parapsoriasis lesions and healthy skin microbiomes.
Conclusions:
- Parapsoriasis is not associated with significant alterations in the cutaneous bacterial microbiome.
- Interpersonal variation in the skin microbiome was notable.
- Further research may explore other factors influencing parapsoriasis pathogenesis.
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