Related Experiment Video

Updated: Mar 7, 2026

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
08:17

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Published on: August 25, 2017

11.6K

Polycyclic aromatic hydrocarbons exposure, oxidative stress, and asthma in children

I-Jen Wang1,2,3, Wilfried J J Karmaus4, Chen-Chang Yang5,6

  • 1Department of Pediatrics, Taipei Hospital, Ministry of Health and Welfare, Taipei, Taiwan, Republic of China. wij636@gmail.com.

International Archives of Occupational and Environmental Health
|February 9, 2017
PubMed

Insights

Polycyclic aromatic hydrocarbons (PAHs) exposure in children is linked to increased oxidative stress and higher risks of asthma. Oxidative stress appears to mediate the relationship between PAH exposure and asthma development.

Area of Science:

  • Environmental Health
  • Toxicology
  • Pediatric Health

Background:

  • Polycyclic aromatic hydrocarbons (PAHs) are environmental pollutants with known carcinogenic and teratogenic effects.
  • The impact of PAHs on the immune and respiratory systems, particularly in children, remains under-investigated.

Purpose of the Study:

  • To investigate the association between PAH exposure and IgE levels and asthma in children.
  • To examine the link between PAH exposure and the oxidative stress marker 8-hydroxy-2'-deoxyguanosine (8OHdG).
  • To explore potential sex-based differences in these associations.

Main Methods:

  • Recruitment of 453 kindergarten children.
  • Measurement of urinary 1-hydroxypyrene (1-OHP) as a biomarker for PAH exposure using UPLC-MS/MS.
  • Assessment of serum IgE, urinary 8OHdG via ELISA, and asthma status.

Main Results:

  • Positive associations were found between PAH exposure (1-OHP) and both oxidative stress (8OHdG) and IgE levels.
  • PAH exposure was significantly associated with an increased odds of asthma (OR 1.42).
  • Mediation analysis indicated that 35% of the effect of PAH exposure on asthma is mediated by 8OHdG.

Conclusions:

  • PAH exposure may contribute to increased oxidative stress in children.
  • PAH exposure is potentially linked to the induction of asthma, with oxidative stress playing a mediating role.
Abstract

Keywords:
8OHdGAsthmaIgE levelsOxidative stressPAHs

More Related Videos

Measuring Carbon Content in Airway Macrophages Exposed to Carbon-Containing Particulate Matters05:18

Measuring Carbon Content in Airway Macrophages Exposed to Carbon-Containing Particulate Matters

Published on: July 12, 2024

903
Visualizing Field Data Collection Procedures of Exposure and Biomarker Assessments for the Household Air Pollution Intervention Network Trial in India09:33

Visualizing Field Data Collection Procedures of Exposure and Biomarker Assessments for the Household Air Pollution Intervention Network Trial in India

Published on: December 23, 2022

3.0K

Related Concept Videos

Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.6K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
4.9K
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.7K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.5K
Types of Toxins01:36

Types of Toxins

Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
3.9K
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
3.6K