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Updated: Mar 7, 2026

Phenotypic Characterization of Macrophages from Rat Kidney by Flow Cytometry
Published on: October 18, 2016
Macrophage heterogeneity and renin-angiotensin system disorders
Mark D Wright1, Katrina J Binger2
1Department of Immunology, Monash University, Prahran, Victoria, Australia.
Abstract:
Macrophages are heterogeneous innate immune cells which are important in both the maintenance of tissue homeostasis and its disruption, by promoting tissue inflammation and fibrosis. The renin-angiotensin system is central to the pathophysiology of a large suite of diseases, which are driven in part by large amounts of tissue inflammation and fibrosis. Here, we review recent advances in understanding macrophage heterogeneity in origin and function, and how these may lead to new insights into the pathogenesis of these chronic diseases.
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