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Rhd and C/cE/e genotyping in Slovenian population

Ruth Rebeka Rupreht1, Brigitte Henrica Wilhelmina Faas2, Vesna Bojanič1

  • 1Blood Transfusion Centre of Slovenia, Šlajmerjeva 6, SI-1105 Ljubljana, Slovenia, , , , , , SI.

Pflugers Archiv : European Journal of Physiology
|February 9, 2017
PubMed

The Rhesus (Rh) blood group system is, after ABO, clinically most important. Alloantibodies directed against Rh antigens are the major cause of a haemolytic disease of newborn (HDN) and of transfusion reactions. In search for novel methods for Rh genotyping we started to compare Rh genotypes identified from different tissues and Rh phenotypes. Genotypes determined from blood samples with PCR based RhD, C/c and E/e genotyping methods were compared with serologically identified phenotypes (N=32). With two exceptions the results of phenotyping and genotyping were in concordance. Two Rh serotypes from a Slovenian family that were unexpected according to the Mendelian laws were characterised genotypically. The two family members were suspected to have a chromosomal deletion on RH gene locus.

Keywords:
Key words Rhesus (Rh)PCR DNA typingRHCERHDSlovenian population

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