Related Experiment Video

Updated: Mar 7, 2026

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs
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Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

Published on: October 31, 2025

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Fluid restriction for treatment of preterm infants with chronic lung disease

Keith J Barrington1, Etienne Fortin-Pellerin2, Thomas Pennaforte3

  • 1Department of Pediatrics, CHU Ste-Justine, 3175 Cote Ste Catherine, Montreal, QC, Canada, H3T 1C5.

The Cochrane Database of Systematic Reviews
|February 9, 2017
PubMed

Insights

Fluid restriction is not supported for infants with bronchopulmonary dysplasia (BPD). Current evidence shows no benefits for clinical outcomes in these preterm infants.

Area of Science:

  • Neonatology
  • Pediatric Pulmonology
  • Critical Care Medicine

Background:

  • Bronchopulmonary dysplasia (BPD) is a chronic lung disease in preterm infants.
  • Fluid restriction is a common but debated management strategy for BPD.

Purpose of the Study:

  • To evaluate the effectiveness of fluid restriction in improving clinical outcomes for infants with BPD.
  • To determine if fluid restriction impacts mortality, oxygen dependence, or other secondary outcomes.

Main Methods:

  • A systematic review of randomized and quasi-randomized controlled trials was conducted.
  • Searches included major databases (CENTRAL, MEDLINE, Embase, CINAHL) up to February 2016.
  • One trial involving 60 preterm infants with persistent oxygen requirements was identified.

Main Results:

  • The single included trial compared standard (180 mL/kg/day) versus concentrated (145 mL/kg/day) formula.
  • No data were available for the primary outcome (mortality or oxygen at 36 weeks' postmenstrual age).
  • No significant effects were observed for any secondary outcomes, and the evidence quality was low.

Conclusions:

  • There is currently insufficient evidence to support the practice of fluid restriction in managing infants with BPD.
  • Further high-quality research is needed to clarify the role of fluid management in BPD.
Abstract

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