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Valsartan with sacubitril, an angiotensin receptor neprilysin inhibitor, is now approved to replace ACE inhibitors. It reduces hospitalisation and death risk in symptomatic heart failure patients with reduced ejection fraction.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Chronic heart failure (CHF) management requires optimizing treatment strategies.
- Patients with reduced ejection fraction (HFrEF) often remain symptomatic despite standard therapy.
Purpose of the Study:
- To provide a correction regarding the use of angiotensin receptor neprilysin inhibitors in CHF management.
- To clarify the role of valsartan with sacubitril in HFrEF treatment.
Main Methods:
- Correction of previously published information on heart failure treatment.
- Reference to established clinical guidelines and research (Ponikowski et al 2016).
Main Results:
- Valsartan with sacubitril is an approved angiotensin receptor neprilysin inhibitor.
- It serves as a replacement for angiotensin-converting enzyme (ACE) inhibitors.
- It further reduces hospitalisation and death risk in specific ambulatory heart failure populations.
Conclusions:
- Angiotensin receptor neprilysin inhibitors represent an advancement in HFrEF therapy.
- This class of drugs offers improved outcomes for symptomatic patients on optimal therapy.
Abstract:
There was an error in our CPD article Chronic heart failure part 2: treatment and management (11 January). On page 55, the first sentence in the angiotensin receptor neprilysin inhibitor section should read: Valsartan with sacubitril is an angiotensin receptor neprilysin inhibitor that has recently been approved for use as a replacement for ACE inhibitors, to further reduce the risk of hospitalisation and death in ambulatory patients with heart failure and an ejection fraction ≤35% who remain symptomatic despite optimal treatment with an ACE inhibitor, a beta-blocker and an aldersterone antagonist (Ponikowski et al 2016).
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