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Updated: Mar 7, 2026

Knee Arthrocentesis in Adults
Published on: February 25, 2022
Topical versus intravenous tranexamic acid in total knee arthroplasty
Sanjay Meena1, Francesco Benazzo2, Saumitra Dwivedi3
11 Department of Orthopaedics, Lady Hardinge Medical College and Associated Hospitals, Connaught Place, New Delhi, India.
Purpose:
The aim of this meta-analysis is to examine the efficacy and safety of intra-articular tranexamic acid (TXA) when compared to intravenous (IV) route.
Methods:
The literature search was conducted using PubMed, Cochrane Library, MEDLINE, EMBASE and China National Knowledge Infrastructure (CNKI). All randomized controlled trials evaluating the effectiveness of topical route and IV route of TXA administration were included.
Results:
Eight randomized clinical trials comprising of 857 patients were included in this analysis. We found no statistically significant difference in terms of total blood loss, drain output, transfusion requirement, thromboembolic complication, tourniquet time and surgical duration.
Conclusion:
Topical TXA has a similar efficacy to IV-TXA in reducing total blood loss, drain output, transfusion rate and haemoglobin drop without any increase in thromboembolic complications.
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