Related Experiment Video
Updated: Mar 7, 2026
06:52
Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres
Published on: July 22, 2020
7.1K
Lung Cancer Stem Cells: An Epigenetic Perspective
Samriddhi Shukla1, Sajid Khan1, Sonam Sinha1
1Laboratory of Cancer Epigenetics, Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India.
Current Cancer Drug Targets
|February 9, 2017
Summary
Lung cancer stem cells (CSCs) drive mortality through drug resistance and relapse. Epigenetic modifications are key to their maintenance, offering potential therapeutic targets.
Area of Science:
- Oncology
- Molecular Biology
- Epigenetics
Background:
- Lung cancer is a leading cause of cancer mortality.
- Drug resistance and tumor relapse are major challenges in lung cancer treatment.
- Lung cancer stem cells (CSCs) are implicated in these poor outcomes.
Purpose of the Study:
- To review the origin and maintenance mechanisms of lung CSCs.
- To discuss the role of epigenetic modifications in lung CSCs.
- To summarize lung CSC markers and therapeutic strategies.
Main Methods:
- Literature review of research on lung CSCs.
- Analysis of studies on epigenetic regulation in cancer stem cells.
- Synthesis of information on CSC markers and targeted therapies.
Main Results:
- Lung CSCs are difficult to distinguish from normal lung epithelium.
- Specific stem cell markers aid in lung CSC identification.
- Epigenetic modifications are crucial for maintaining lung CSC populations.
Conclusions:
- Understanding lung CSC origin and epigenetic maintenance is vital.
- Targeting lung CSCs offers a promising therapeutic avenue.
- Further research into CSC markers and therapies is warranted.
Related Concept Videos
02:40Cancer Stem Cells and Tumor Maintenance
6.2K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
6.2K
02:53Adaptive Mechanisms in Cancer Cells
7.2K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
7.2K
01:18Distinctive Features of Adult Stem Cells vs Cancer Stem Cells
4.8K
A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
4.8K
01:37Epigenetic Regulation
4.0K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
4.0K
01:46Epigenetic Regulation
34.1K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
34.1K
02:39lncRNA - Long Non-coding RNAs
10.1K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.1K