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Primary Systemic Amiyloidosis with Bullous Lesions
Indian Journal of Dermatology, Venereology and Leprology
|February 9, 2017
Summary
Primary systemic amyloidosis with bullous lesions, a rare manifestation associated with multiple myeloma, showed encouraging response to melphalan and prednisolone therapy. The adult patient remained well over two years post-diagnosis.
Area of Science:
- Hematology
- Oncology
- Dermatology
Background:
- Primary systemic amyloidosis is a rare plasma cell disorder.
- Bullous lesions are an uncommon manifestation of systemic amyloidosis.
- Multiple myeloma is a malignant proliferation of plasma cells.
Observation:
- An adult patient presented with primary systemic amyloidosis manifesting as bullous lesions.
- The patient had concurrent multiple myeloma.
Findings:
- The patient received treatment with melphalan and prednisolone.
- A positive therapeutic response was observed.
Implications:
- This case highlights the potential for bullous lesions in systemic amyloidosis.
- Melphalan and prednisolone may be an effective treatment regimen for this rare condition.
- Long-term remission is achievable with appropriate therapy.
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