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For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
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Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
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Updated: Mar 7, 2026

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
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Lichen Planus and Glucose Tolerance.

R K Jain, P Datta, Ratan Singh

    Indian Journal of Dermatology, Venereology and Leprology
    |February 9, 2017
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    Summary
    This summary is machine-generated.

    Sixty percent of patients with lichen planus exhibited abnormal glucose tolerance compared to healthy controls. This glucose intolerance was linked to recent disease onset, not the extent of skin involvement.

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    Area of Science:

    • Endocrinology
    • Dermatology
    • Metabolic Disorders

    Background:

    • Lichen planus is an inflammatory condition affecting skin and mucous membranes.
    • Glucose metabolism disturbances may be associated with inflammatory diseases.

    Purpose of the Study:

    • To investigate glucose tolerance in patients with lichen planus.
    • To compare glucose tolerance between lichen planus patients and healthy controls.

    Main Methods:

    • Steroid-primed glucose tolerance test administered to 20 lichen planus patients and 5 healthy controls.
    • Assessment of glucose tolerance levels.

    Main Results:

    • 60% of lichen planus patients demonstrated abnormal glucose tolerance.
    • No abnormal glucose tolerance was observed in the control group.
    • Glucose intolerance correlated with recent disease onset, but not disease extent.

    Conclusions:

    • Patients with lichen planus have a higher prevalence of glucose intolerance.
    • Early-stage lichen planus may be associated with metabolic changes.
    • Further research into the link between lichen planus and glucose metabolism is warranted.