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Related Concept Videos

Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
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Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

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Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
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Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

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Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
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Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

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Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
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Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

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Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
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Bacterial Phylum Spirochaetes01:30

Bacterial Phylum Spirochaetes

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Spirochetes, unique bacteria in the phylum Spirochaetes, are gram-negative, motile, tightly coiled, slender, and flexible. They inhabit aquatic sediments and animals, with some causing diseases like syphilis. Spirochetes are classified into eight genera based on habitat, pathogenicity, phylogeny, and characteristics.Their distinctive motility arises from endoflagella, located within the cell’s periplasm. These endoflagella anchor at the cell poles and extend along the cell length, encased...
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Related Experiment Video

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DNA Fingerprinting of Mycobacterium leprae Strains Using Variable Number Tandem Repeat VNTR - Fragment Length Analysis FLA
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Histoid Leprosy in Varanasi.

V V Singh, Gurmoban Singh, Pammjit Kaur

    Indian Journal of Dermatology, Venereology and Leprology
    |February 9, 2017
    PubMed
    Summary

    Histoid leprosy, a rare form of leprosy, was identified in 1.2% of registered cases. This study found no link between histoid leprosy and DDS-resistant Mycobacterium leprae strains.

    Area of Science:

    • Dermatology
    • Infectious Diseases
    • Microbiology

    Background:

    • Leprosy remains a significant global health concern, with various clinical presentations.
    • Histoid leprosy is a less common, distinct form of lepromatous leprosy.
    • Understanding the epidemiology and characteristics of histoid leprosy is crucial for effective control.

    Purpose of the Study:

    • To determine the incidence of histoid leprosy in a specific patient population.
    • To analyze the clinical and bacteriological features of histoid leprosy cases.
    • To investigate potential correlations between histoid leprosy and dapsone (DDS) resistance in Mycobacterium leprae.

    Main Methods:

    • Retrospective analysis of leprosy cases registered over one year.
    • Identification and classification of histoid leprosy cases based on clinical and histopathological criteria.

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  • Assessment of bacteriological and morphological indices in affected patients.

    • Main Results:

    • Seventeen cases of histoid leprosy were identified, representing 1.2% of 1394 total leprosy cases.
    • The lepromatous index was 13.9% among the 194 lepromatous leprosy cases.
    • Approximately 50% of histoid leprosy patients had no prior antileprosy treatment; high bacteriological and moderate morphological indices were observed.
    • No correlation was found between histoid leprosy and DDS-resistant Mycobacterium leprae strains.

    Conclusions:

    • Histoid leprosy constitutes a small but identifiable proportion of leprosy cases.
    • The clinical presentation and bacteriological load in histoid leprosy warrant further investigation.
    • Current findings suggest that DDS resistance is not a significant factor in the occurrence of histoid leprosy in this cohort.