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The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
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In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...
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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
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Quantification of Hypopigmentation Activity In Vitro
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Vitiligo in a Pigmented Nevus.

K Pavithran

    Indian Journal of Dermatology, Venereology and Leprology
    |February 9, 2017
    PubMed
    Summary
    This summary is machine-generated.

    Vitiligo can develop within Becker's nevus, a pigmented skin condition. This case report explores potential causes for this depigmentation.

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    Area of Science:

    • Dermatology
    • Pigmentary disorders

    Background:

    • Becker's nevus is a common congenital melanosis characterized by hyperpigmentation.
    • Vitiligo is an autoimmune condition causing depigmentation of the skin.

    Observation:

    • A rare case of vitiligo developing within a pre-existing Becker's nevus is presented.
    • The depigmentation occurred in a distinct patch within the larger pigmented area.

    Findings:

    • The co-occurrence suggests a potential link or specific susceptibility within Becker's nevus.
    • Possible mechanisms include autoimmune responses targeting melanocytes in the nevus or altered microenvironment.

    Implications:

    • Understanding this association may offer insights into vitiligo pathogenesis.
    • Further research could explore diagnostic or therapeutic strategies for such combined presentations.