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Prognostic significance of microRNA-100 in solid tumors: an updated meta-analysis

Jiangfeng Wang1, Miao Yu2, Shanghui Guan1

  • 1Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, People's Republic of China.

Oncotargets and Therapy
|February 9, 2017
PubMed
Abstract

Insights

Lower expression of microRNA-100 (miR-100) is linked to poorer overall survival in solid tumor patients. This finding is particularly significant in non-small-cell lung cancer, epithelial ovarian cancer, and bladder cancer cases.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biomarkers

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression.
  • Dysregulation of miRNAs is implicated in various cancers.
  • microRNA-100 (miR-100) has emerged as a potential biomarker in cancer, but its prognostic significance in solid tumors requires comprehensive evaluation.

Purpose of the Study:

  • To conduct a meta-analysis to determine the prognostic significance of microRNA-100 (miR-100) in patients with solid tumors.
  • To investigate the association between miR-100 expression levels and overall survival (OS).

Main Methods:

  • A systematic literature search was performed in PubMed, Embase, and Web of Science up to July 10, 2016.
  • Included studies were assessed for quality using the Newcastle-Ottawa scale.
  • Pooled hazard ratios (HR) with 95% confidence intervals (CI) were calculated using fixed- or random-effects models. Publication bias was assessed using Begg's and Egger's tests.

Main Results:

  • A total of 16 studies comprising 1,501 patients were included in the meta-analysis.
  • Lower expression of miR-100 was significantly associated with poorer OS in solid tumor patients (HR = 1.92; 95% CI = 1.25-2.94).
  • Subgroup analyses revealed this association in non-small-cell lung cancer (NSCLC; HR = 2.46; 95% CI = 1.98-3.06), epithelial ovarian cancer (EOC; HR = 2.29; 95% CI = 1.72-3.04), and bladder cancer (BC; HR = 4.14; 95% CI = 1.85-9.27).

Conclusions:

  • This meta-analysis concludes that reduced miR-100 expression is a significant predictor of poor OS in solid tumors, notably in NSCLC, EOC, and BC.
  • miR-100 demonstrates potential as a prognostic biomarker.
  • miR-100 may represent a future therapeutic target in cancer treatment.
Keywords:
meta-analysismicroRNA-100prognosis

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