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Nanoscale mapping of newly-synthesised phospholipid molecules in a biological cell using tip-enhanced Raman
Naresh Kumar1, Marek M Drozdz2, Haibo Jiang3
1National Physical Laboratory, Hampton Road, Teddington, TW11 0LW, UK. naresh.kumar@npl.co.uk naresh.kumar.gautam@gmail.com.
Abstract:
Nanoscale chemical mapping of newly-synthesised phospholipid molecules inside a mammalian cell is demonstrated using tip-enhanced Raman spectroscopy (TERS) for the first time using mouse pre-adipocyte cells as a model system. Newly-synthesised membrane phospholipid distribution within a pre-adipocyte cell is mapped with <20 nm spatial resolution, overcoming the diffraction limit of confocal Raman spectroscopy via plasmonic enhancement of Raman signals at a TERS tip-apex.
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