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Related Concept Videos

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

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Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
306
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
295
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

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Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

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In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
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Dose-dependent decrease in mortality with no cognitive or muscle function improvements due to dietary EGCG

Brandt D Pence1,2, Tushar K Bhattacharya3,4, Pul Park3,4

  • 1a Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquee, Nutrition Et Metabolisme
|February 9, 2017
PubMed
Summary
This summary is machine-generated.

Epigallocatechin gallate (EGCG) supplementation did not improve cognitive or muscle function in aged mice. However, EGCG significantly increased survival rates in a dose-dependent manner, suggesting a potential benefit for longevity.

Keywords:
agingcognitiondietary interventionepigallocatechin gallateintervention alimentairemortalitymortalitévieillissementépigallocatéchine gallate

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Area of Science:

  • Gerontology
  • Nutritional Neuroscience
  • Pharmacology

Background:

  • Previous studies suggest potential benefits of epigallocatechin gallate (EGCG) for cognitive and muscle function, particularly with longer interventions or different dosages.
  • However, prior research indicated that a diet containing EGCG and beta-alanine was ineffective in improving cognitive or muscle function in aged mice.
  • This diet did, however, reduce oxidative stress in the brain.

Purpose of the Study:

  • To investigate the efficacy of different doses of EGCG over a prolonged feeding period on cognitive and muscle function in aged mice.
  • To determine if altered EGCG dosage or duration could enhance its previously observed beneficial effects.

Main Methods:

  • Aged Balb/cByJ male mice (21-25 months) were fed diets containing EGCG at 0, 0.091, or 3.67 mg/g for 63 days.
  • Cognitive function was assessed using the Y-maze, active avoidance, and social discrimination tests.
  • Muscle function was evaluated through grip strength, rotarod, and treadmill tests to exhaustion.

Main Results:

  • EGCG administration at tested doses did not significantly alter performance in any of the cognitive tests (Y-maze, active avoidance, social discrimination).
  • No significant improvements in muscle function were observed across grip strength, rotarod, or treadmill tests.
  • EGCG demonstrated a dose-dependent reduction in mortality, with higher doses correlating with increased survival rates.

Conclusions:

  • Epigallocatechin gallate (EGCG) supplementation does not enhance cognitive or muscle function in aged mice under the tested conditions.
  • EGCG significantly improves survival rates in aged mice in a dose-dependent manner.
  • Further research may explore EGCG's mechanisms for improving longevity rather than direct functional improvements.