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Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice

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Early Postoperative Decrease of Serum Albumin Predicts Surgical Outcome in Patients Undergoing Colorectal Resection.

Xiaolong Ge¹, Xujie Dai, Chao Ding

¹Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.

Diseases of the Colon and Rectum

|February 9, 2017

Summary

A 15% reduction in serum albumin within two days after colorectal surgery independently predicts postoperative complications. This finding aids in identifying high-risk patients for safe and early discharge.

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Area of Science:

Surgical outcomes research
Clinical biochemistry
Postoperative care

Background:

A simple, accurate predictor for early and safe postoperative discharge is needed.
Decreased serum albumin post-surgery is common but its predictive value for outcomes is unknown.

Purpose of the Study:

To determine if serum albumin reduction within 2 days post-surgery predicts complications after colorectal surgery.

Main Methods:

Retrospective study of 626 patients undergoing major colorectal surgery.
Univariate, multivariate analyses, and ROC curves to identify risk factors and predict complications.
Evaluated the change in serum albumin (Δalbumin) compared to preoperative levels.

Main Results:

A median Δalbumin of 15% was observed.
Δalbumin ≥15% was an independent predictor of overall postoperative complications (p < 0.01).
Patients with Δalbumin ≥15% had more major complications, higher complication index, longer stays, and increased surgical site infections.

Conclusions:

A 15% reduction in serum albumin within 2 days post-surgery can identify patients at high risk for complications.
This marker facilitates safe and early discharge planning after colorectal surgery.