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A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target
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Hepatitis C Virus Therapy for Decompensated and Posttransplant Patients
Francis Dailey1, Walid S Ayoub
1*Department of Internal Medicine †Liver Transplant Program, Cedars-Sinai Medical Center, Los Angeles, CA.
Journal of Clinical Gastroenterology
|February 9, 2017
Summary
Direct-acting antivirals (DAA) have transformed hepatitis C (HCV) treatment, offering higher efficacy and fewer side effects. This review examines DAA recommendations for patients with decompensated cirrhosis and post-liver transplant, where cure rates remain lower.
Area of Science:
- Hepatology
- Virology
- Clinical Medicine
Background:
- Hepatitis C (HCV) treatment has been revolutionized by direct-acting antivirals (DAA).
- DAAs offer improved tolerability and efficacy compared to previous interferon-based therapies.
- DAAs provide a curative option for patients intolerant to interferon, including those with decompensated cirrhosis and post-liver transplantation.
Purpose of the Study:
- To review current treatment recommendations for HCV in specific patient populations.
- To address the challenges and outcomes of DAA therapy in decompensated cirrhosis and post-liver transplantation settings.
Main Methods:
- Literature review of current clinical guidelines and research.
- Analysis of treatment efficacy and safety data for DAAs in target populations.
Main Results:
- DAA therapy demonstrates high cure rates (>95%) in patients without cirrhosis.
- Cure rates for DAA therapy in patients with decompensated liver disease are lower than in non-cirrhotic patients.
- Specific recommendations for managing HCV in decompensated cirrhosis and post-transplant patients are discussed.
Conclusions:
- DAA therapy is a significant advancement in HCV treatment.
- Further research and optimized treatment strategies are needed for HCV patients with decompensated cirrhosis and post-liver transplantation to improve cure rates.
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