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Quantitative analysis of resistance and cross-resistance to cytotoxic agents by tumour cell lines
1Department of Experimental Pathology, German Cancer Research Center, Heidelberg.
Anticancer Research
|July 1, 1989
Abstract:
The published literature describing the spectrum of resistance and cross-resistance to cytotoxic agents by human and murine tumour cell lines maintained in long-term culture is reviewed. The data available demonstrate that for many cytotoxic agents, especially those of higher molecular weight, cross-resistance is proportional to the degree of resistance against the selecting agent. Furthermore, the degree of cross-resistance correlates with the molecular weight of the drug in adriamycin-, vincristine- and colchicine-resistant cell lines.