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Perindopril Induces TSP-1 Expression in Hypertensive Patients with Endothelial Dysfunction in Chronic Treatment

Valentina Buda1, Minodora Andor2, Lucian Petrescu3

  • 1Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2 EftimieMurgu, 300041 Timisoara, Romania. buda.valentina.oana@gmail.com.

International Journal of Molecular Sciences
|February 9, 2017
PubMed

Insights

Perindopril treatment increased plasma levels of Thrombospondin-1 (TSP-1) in hypertensive patients with endothelial dysfunction. This finding highlights TSP-1 as a biomarker for Perindopril

Area of Science:

  • Cardiovascular Research
  • Pharmacology
  • Biomarker Discovery

Background:

  • Thrombospondin-1 (TSP-1) is an angiogenesis inhibitor with complex roles in cardiovascular disorders (CVDs).
  • Its precise function in CVD physiopathology is not fully understood, potentially due to its multiple cellular interactions.
  • TSP-1 influences NO-mediated signaling, angiogenesis, tissue perfusion, and endothelial cell proliferation.

Purpose of the Study:

  • To quantify the effect of Perindopril on plasma TSP-1 levels in hypertensive patients with endothelial dysfunction.
  • To compare Perindopril's effect on TSP-1 with other antihypertensive drugs (beta-blockers, calcium channel blockers, diuretics).

Main Methods:

  • A comparative study involving hypertensive patients with endothelial dysfunction undergoing chronic treatment.
  • Quantification of plasma TSP-1 levels in patients treated with Perindopril, other antihypertensives, and a control group.

Main Results:

  • Patients treated with Perindopril exhibited significantly increased plasma TSP-1 levels.
  • TSP-1 levels in the Perindopril group were higher compared to both other hypertensive patients and the control group.

Conclusions:

  • Perindopril treatment leads to elevated plasma TSP-1 levels in hypertensive patients with endothelial dysfunction.
  • This suggests TSP-1 as a biomarker reflecting the pleiotropic, anti-proliferative, and anti-inflammatory effects of Perindopril.

Keywords:
TSP-1angiotensin-converting enzyme (ACE) inhibitorsanti-inflammatoryanti-proliferativeantihypertensive drugsendothelial dysfunctionessential arterial hypertensionperindoprilthrombospondin-1

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