Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Colony stimulating factor].

F Takaku1

  • 1Third Dept. of Internal Medicine, Faculty of Medicine, Univeristy of Tokyo.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|November 1, 1989
PubMed
Summary
This summary is machine-generated.

Granulocyte colony-stimulating factors (G-CSF), GM-CSF, and M-CSF accelerate recovery from neutropenia after chemotherapy and transplantation. These factors show efficacy in various blood disorders and may lower cholesterol.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Serum erythropoietin titers in hematological malignancies and related diseases.

International journal of cell cloning·1992
Same author

Increased respiratory burst activity of neutrophils in patients with aplastic anemia: effects of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor.

Experimental hematology·1992
Same author

Production of interleukin 3 and granulocyte-macrophage colony-stimulating factor from stimulated blood mononuclear cells in patients with aplastic anemia.

Experimental hematology·1992
Same author

Correlation of antibodies to ribosomal P protein with psychosis in patients with systemic lupus erythematosus.

Annals of the rheumatic diseases·1992
Same author

Changes of enzyme activity levels in red blood cells in hemodialysis patients by recombinant human erythropoietin.

Nihon Jinzo Gakkai shi·1992
Same author

[Present status and future aspects of clinical use of cytokines].

Nihon rinsho. Japanese journal of clinical medicine·1992
Same journal

[A Case of Pulmonary Epithelioid Hemangioendothelioma Associated with Multiple Cancers].

Gan to kagaku ryoho. Cancer & chemotherapy·2026
Same journal

[Long-Term Survival in Three Cases with Pulmonary Metastases from Colorectal Cancer Given Low-Dose S-1 Under a Regimen Combining a Carbohydrate-Restricted Ketogenic Diet, Metformin, Vitamin D, Eicosapentaenoic Acid, and Other Complementary Therapies].

Gan to kagaku ryoho. Cancer & chemotherapy·2026
Same journal

[Preventive Effect of Saline Eye Wash for Eye Symptoms Due to High-Dose and Intermediate-Dose Cytarabine Therapy].

Gan to kagaku ryoho. Cancer & chemotherapy·2026
Same journal

[Examination of Factors Affecting the Efficacy of Naldemedine Tosilate Tablets for Opioid-Induced Constipation].

Gan to kagaku ryoho. Cancer & chemotherapy·2026
Same journal

[Recent Advances in the Treatment of HER2-Altered Solid Tumors].

Gan to kagaku ryoho. Cancer & chemotherapy·2026
Same journal

[BRAF-Mutant Solid Tumor].

Gan to kagaku ryoho. Cancer & chemotherapy·2026
See all related articles

Area of Science:

  • Hematology
  • Oncology
  • Immunology

Context:

  • Hematopoietic growth factors, including G-CSF, GM-CSF, and M-CSF, play crucial roles in regulating blood cell production.
  • Their clinical application has expanded beyond supportive care in cancer treatment.

Purpose:

  • To summarize the clinical utility of G-CSF, GM-CSF, and M-CSF.
  • To explore their efficacy in accelerating neutrophil recovery, managing hematological disorders, and potential roles in cancer therapy and cholesterol reduction.

Summary:

  • Colony-stimulating factors (CSFs) effectively hasten neutrophil recovery post-chemotherapy and bone marrow transplantation.
  • CSFs demonstrated therapeutic benefits in aplastic anemia, myelodysplastic syndrome (MDS), and pediatric idiopathic neutropenia.
  • G-CSF showed combined efficacy with anti-leukemic agents for acute non-lymphocytic leukemia (ANLL) and in conditioning for bone marrow transplantation.

Related Experiment Videos

  • GM-CSF and M-CSF were discussed for potential use in stimulating anti-cancer monocyte-macrophage functions.
  • Both GM-CSF and M-CSF exhibited cholesterol-lowering effects in preclinical and clinical studies.

    • Impact:

    • These findings highlight the multifaceted clinical applications of CSFs in hematology and oncology.
    • The potential cholesterol-lowering effect of GM-CSF and M-CSF warrants further investigation.
    • CSF therapy represents a significant advancement in managing neutropenia and certain hematological malignancies.