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Related Concept Videos

Brain Imaging01:14

Brain Imaging

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Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
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Selective TMS-induced modulation of functional connectivity correlates with changes in behavior.

Puiu F Balan1, Annelies Gerits1, Dante Mantini1

  • 1Laboratory for Neuro-and Psychophysiology, KU Leuven Medical School, Campus Gasthuisberg, Leuven 3000, Belgium.

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|February 10, 2017
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Summary

Functional connectivity (FC) modulation via frontal eye fields (FEF) transcranial magnetic stimulation (TMS) quantitatively altered saccadic behavior in monkeys. FEF-cTBS decreased FC, improved performance, and compensated choice biases, revealing insights into brain network regulation.

Keywords:
FEFFunctional connectivitySaccadic choice biascTBSfMRI

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Area of Science:

  • Neuroscience
  • Cognitive Science
  • Systems Neuroscience

Background:

  • Functional connectivity (FC) is increasingly used in research, but its link to behavior remains unclear.
  • Understanding how artificial modulation of FC affects behavior is crucial for both fundamental and clinical applications.

Purpose of the Study:

  • To test if artificial modulation of FC correlates quantitatively with behavioral changes.
  • To investigate the effects of perturbing frontal eye fields (FEF) on behavior and resting-state functional connectivity (FC).

Main Methods:

  • Monkeys underwent behavioral and resting-state fMRI experiments.
  • Unilateral continuous theta burst transcranial magnetic stimulation (cTBS) was used to perturb the FEF offline.
  • Saccadic behavior and FC changes were analyzed before and after stimulation.

Main Results:

  • FEF-cTBS induced specific decreases in FC, both intra- and inter-hemispherically.
  • Stimulation improved saccadic performance and compensated for intrinsic choice biases, irrespective of bias direction.
  • FC decreases predicted the direction and magnitude of behavioral shifts, with effects dependent on stimulation side, bias, and individual monkeys.

Conclusions:

  • Naturally occurring saccade biases influence FC changes following FEF-cTBS.
  • FEF-cTBS-induced FC decreases can predict behavioral shifts, suggesting a regulatory role.
  • The findings suggest FEF-cTBS primarily adjusts inter-hemispheric imbalances, reconciling improved performance with decreased connectivity.