Related Experiment Video

Updated: Mar 7, 2026

Preparation of Myeloid Derived Suppressor Cells MDSC from Naive and Pancreatic Tumor-bearing Mice using Flow Cytometry and Automated Magnetic Activated Cell Sorting AutoMACS
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Preparation of Myeloid Derived Suppressor Cells MDSC from Naive and Pancreatic Tumor-bearing Mice using Flow Cytometry and Automated Magnetic Activated Cell Sorting AutoMACS

Published on: June 18, 2012

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The clinical evidence for targeting human myeloid-derived suppressor cells in cancer patients

Richard P Tobin1, Dana Davis1, Kimberly R Jordan2

  • 1Department of Surgery, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado, USA; and.

Journal of Leukocyte Biology
|February 10, 2017
PubMed

Insights

Myeloid-derived suppressor cells (MDSCs) hinder cancer treatment efficacy. Targeting these cells in humans shows promise for improving anti-cancer therapy outcomes, though more clinical data is needed.

Area of Science:

  • Oncology
  • Immunology

Background:

  • Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells that impede effective cancer treatment.
  • High MDSC frequencies correlate with reduced progression-free survival (PFS) and overall survival (OS) in cancer patients.

Purpose of the Study:

  • To review current data on MDSCs from human clinical trials.
  • To explore the potential of targeting MDSCs to enhance cancer therapy efficacy in humans.

Main Methods:

  • Literature review of existing human clinical trial data concerning MDSCs.
  • Analysis of evidence supporting MDSC-targeted strategies in cancer therapy.

Main Results:

  • Experimental evidence in mice suggests reducing MDSCs improves anti-cancer therapy.
  • Limited but emerging data from human clinical trials are discussed regarding MDSC targeting.

Conclusions:

  • MDSCs represent a significant challenge in cancer treatment.
  • Targeting MDSCs may offer a viable strategy to improve the efficacy of cancer therapies in human clinical settings.
Keywords:
MDSCimmunosuppressionimmunotherapyoncology

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