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Flow diverter implantation in a rat model of sidewall aneurysm: a feasibility study
René Aquarius1,2, Debby Smits3, Matthew J Gounis4,5
1Department of Neurosurgery, Radboud University Medical Center, Nijmegen, The Netherlands.
Background:
More challenging animal models are needed to elucidate the efficacy of flow diverter (FD) designs and the mechanisms behind observed complications. The purpose of this study is to demonstrate the feasibility of implanting a FD in a sidewall aneurysm rat model.
Methods:
An end-to-side anastomosis was created in the abdominal aorta of 36 rats using a decellularized donor pouch. A FD was subsequently implanted.
Results:
After up to 3 months of follow-up, we observed that rats displayed normal growth and behavior. Mortality within the groups was low (2 rats, 5.6%). All aneurysms thrombosed after FD implantation and showed progressive soft tissue replacement of the thrombus during follow-up. The abdominal aortas remained patent.
Conclusions:
This model can be used to test the effects of FDs in future studies.
