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Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

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Glucose-responsive hydrogel electrode for biocompatible glucose transistor.

Taira Kajisa¹, Toshiya Sakata²

¹PROVIGATE Inc., Department of Research and Development , Tokyo , Japan.

Science and Technology of Advanced Materials

|February 10, 2017

Summary

This study presents a highly sensitive and biocompatible glucose sensor using a field-effect transistor (FET) with a functionalized hydrogel. This novel hydrogel FET offers precise glucose detection for potential use in wearable devices.

Keywords:

208 Sensors and actuators 30 Bio-inspired and 600 Others Field effect transistor biocompatibility biomedical materials glucose hydrogel phenylboronic acid

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Area of Science:

Biomedical Engineering
Materials Science
Sensor Technology

Background:

Accurate glucose monitoring is crucial for diabetes management.
Existing glucose sensors face challenges with sensitivity, biocompatibility, and protein interference.
Field-effect transistors (FETs) offer high sensitivity for charge detection.

Purpose of the Study:

To develop a highly sensitive and biocompatible glucose sensor.
To utilize a functionalized hydrogel on a FET for specific glucose detection.
To optimize the hydrogel composition for enhanced performance.

Main Methods:

Fabrication of a semiconductor-based FET device.
Coating the FET's gate electrode with a copolymerized hydrogel of HEMA and VPBA.
Optimizing the hydrogel mixture ratio for glucose responsiveness and biocompatibility.
Characterizing the FET's response to varying glucose concentrations and protein interference.

Main Results:

The hydrogel FET demonstrated high sensitivity to glucose across a concentration range of 10 μM to 40 mM.
A negative shift in gate surface potential correlated with increased glucose levels due to diol-binding.
The hydrogel effectively suppressed signal noise from non-specific protein adsorption (e.g., albumin).

Conclusions:

The developed hydrogel FET is a promising candidate for highly sensitive and biocompatible glucose sensing.
Its ability to minimize protein interference enhances reliability.
Potential applications include non-invasive wearable sensors like contact lenses and skin patches.